Probiotics as Potential Therapies in Human Gastrointestinal Health

Authors

  • Eswara Murali S Department of Pharmacology A.M. Reddy Memorial College of Pharmacy Petlurivaripalem, Narasaraopet, Andhra Pradesh, India.
  • Kavitha BTVV Department of Pharmacology A.M. Reddy Memorial College of Pharmacy Petlurivaripalem, Narasaraopet, Andhra Pradesh, India.
  • Srikanth J G Department of Pharmacology A.M. Reddy Memorial College of Pharmacy Petlurivaripalem, Narasaraopet, Andhra Pradesh, India.
  • Velmani G Department of Pharmacology A.M. Reddy Memorial College of Pharmacy Petlurivaripalem, Narasaraopet, Andhra Pradesh, India.

Keywords:

Antibiotics induced ulcer, Bacterial translocation, Prebiotics

Abstract

Nowadays, the treatment of gastrointestinal disorders with probiotics is a widely used remedy for intestinal complications in humans. This essential sources of microorganisms was originally developed for the treatment of health illness, based on the ability to functioning the normal pathway of intestine moreover, the clinical effects were reported as a remarkable advancement over commonly used treatment in GIT problems. Subsequently, it was realized that the clinical applicability of the enhanced intestinal floral development of used probiotics has been expanded to the therapeutic management of other gastrointestinal disorders, including cancer, heart failure etc.

References

1. Gibson GR, Roberfroid MB, Dietary

Modulation of the Human Colonic Microbiota.

Introducing the concept of prebiotics. J nutr

;125:1401-12.

Erika Isolauri, Yelda Sütas, Pasi Kankaanpää,

Heikki Arvilommi and Seppo Salminen

Probiotics: effects on immunity. American

Journal of Clinical Nutrition, Vol. 73, No.2,

S-450s, February 2001

Mailn M, Verronen P, Mykkanen H, et al.

Increased Bacterial Urease activity in faeces in

juvenile chronic arthritis: evidence of altread

intestinal microflora. Br j

rheumatol.1996;35:689-94.

Collins MD, et al. Reduces the risk of

antibiotic, allergic and infectious diarrhoea.

Am J Clin Nutr 1999;69(suppl):1052s-7s.

Fuller R, Probiotics in man and animals. J Appl

Bacteriol - 01-MAY-1989; 66(5): 365- 78.

Sanders ME, Considerations for use of

probiotic bacteria to modulate human health. J

nutr 2000; 130(2s suppl):384s-390s.

Mauro Cassaro, Massimo Rugge, et al.

Topographic Patterns of Intestinal Metaplasia

and Gastric Cancer. The American Journal of

Gastroenterology, Vol 95, No.6, 2000, pp

-8.

Glenn R. Gibson and Marcel B. Roberfroid

Dietary Modulation of the Human Colonic

Microbiota: Introducing the Concept of

Prebiotics. J. Nutr. 1995 125: 1401-1412

Wullt M, Hagslatt ML, Odenholt

I:Lactobacillus plantarum 299v for the

treatment of recurrent Clostridium difficileassociated diarrhoea: a double-blind, placebocontrolled trial. Scand J Infect Dis 2003,

:365-367.

McFarland LV, Surawicz CM, Greenberg RN,

et al.: A randomized placebo-controlled trial of

Saccharomyces boulardii in combination with

standard antibiotics for Clostridium difficile

disease. JAMA 1994, 271:1913-1918

Adams M R, Hall C J, Growth inhibition of

food pathogens by lacticacid and acetic acid

and their mixtures. International journal of

food science & technology. Vol,23, issue 3,

pages 287-292.

Christine V. Salmond, Rohan G. Kroll, and Ian

R. Booth .The Effect of Food Preservatives on

pH Homeostasis in Escherichia coli.J Gen

Microbiol 1984 130: 2845-2850

14. Salminen S, Bouley C, Boutron Ruault

MC, Cummings JH, Franck A, Gibson

GR,Isolauri E, Moreau MC, Roberfroidm,

Rowland I. functional food science and

gastrointestinal physiology and function. Br J

Nutr , 1998,80(suppl 1):147-71.

Solauri E, Majamaa H, Arvola T, et al.

lactobacillus casei GG reverses increased

intestinal permeability induced by cow milk in

suckling rats. Gastroenterology,

;105:1643-50.

Mossman TR, Cherwinski H, Bond MW, et al.

Two types of murine helper T cell clone. I.

Definition according to profiles of lymphokine

activities and secreted proteins. J Immunol

; 136: 2348-57.

Perdigon G, de Macias N, Alvarez S, Oliver G,

de Ruiz Holgado AA. 1986. Effect on per

orally administered lactobacilli on macrophage

activity in mice. Infect. Immun. 53:404-10.

Perdigon G, de Macias N, Alvarez S, Oliver G,

de Ruiz Holgado AA. 1988. Systemic

augmentation of the immune response in mice

by feeding fermented milks with Lactobacillus

casei and Lactobacillus acidophilus.

Immunology. 63:17-23.

Sütas Y, Soppi E, Korhonen H, et al.

Suppression of lymphocyte proliferation in

vitro by bovine caseins hydrolysed with

Lactobacillus GG-derived enzymes. J Allergy

Clin Immunol 1996; 98:216-24

Sütas Y, Hurme M, Isolauri E. Scand J

Immunol. 1996 Jun;43(6):687-9.Down

regulation of anti-CD3 antibody-induced IL-4

production by bovine caseins hydrolysed with

Lactobacillus GG-derived enzymes.

Fedork N, Madsen KL, Probiotics and

Prebiotics in gastrointestinal disorders. Curr

opin gastroenterol 2004;20:149-55.

Isolauri E, Sutas Y, Kankaanpaa P, et al.

Probiotics: effect on immunity. Am j clin nutr

;73(suppl):444S-50S.

Hu FB, Stampfer MJ, Manson JE, Rimm EB,

Wolk A, Colditz GA, et al. Dietary intake of

alpha-linolenic acid and risk of fatal ischemic

heart disease among women.

McFarland LV, Surawicz CM, Greenberg RN,

et al.: A randomized placebo-controlled trial of

Saccharomyces boulardii in combination with

standard antibiotics for Clostridium difficile

disease. JAMA 1994, 271:1913-1918.

Castagliuolo I, Lamont JT, Nikulasson ST, et

al. Saccharomyces boularidii protease inhibits

clostridium difficile toxin A effects in the rat

ileum. Infect immune 1996;64:5225-32.

Castagliuolo I, Riegler MF, Valenick L, et al.

Saccharomyces boularidii protects inhibits the

effects of clostridium difficille toxin a and b in

human colonic mucosa. Infect immune

;67:302-07.

Probiotics.Availableonhttp://www.probiotics.c

om/html/background/scientificsummary .html

.accessed on 08/12/2004

Lactobacillus acidophilus. Danone world

newsletter 1997:13(online) available on

http://www.danonevitapole.com assessed on

/12/2004

Dunne C, Shanhan F, Biotherapeutic agents in

the treatment of gasterointestinal disorders.

Current treatment options in infectious disease

; 5:183-88.

Blehaut H, Massot J, Elmer GW, et al.

Disposition kinetics of saccharomyces

boulardii in man and rat. Biopharm drug dispos

;104:353-64.

McFarland LV, Surawicz CM, Greenberg RN,

et al.: A randomized placebo-controlled trial of

Saccharomyces boulardii in combination with

standard antibiotics for Clostridium difficile

disease. JAMA 1994, 271:1913-1918.

Brady LJ, Gallaher DD, Busta FF (February

. "The role of probiotic cultures in the

prevention of colon cancer". J. Nutr. 130 (2S

Suppl): 410S–414S

Rolfe, R. D. The Role of Probiotic Cultures in

the Control of Gastrointestinal Health. Journal

of Nutrition. 2000;130:396S-402S.)

Colum Dunne, Liam O'Mahony, Lisa Murphy,

Gerardine Thornton, Darrin Morrissey, Sile

O'Halloran, Maria Feeney, Sarah Flynn, Gerald

Fitzgerald, Charles Daly, Barry Kiely, Gerald

C O'Sullivan, Fergus Shanahan and J Kevin

Collins. In vitro selection criteria for probiotic

bacteria of human origin: Correlation with in

vivo findings. American Journal of Clinical

Nutrition, Vol. 73, No. 2, 386S-392s, February

Hamilton-Miller JM: The role of probiotics in

the treatment and prevention of Helicobacter

pylori infection. Int J Antimicrob Agents 2003,

:360-366.

Ushiyama A, Tanaka K, Aiba Y, et

al.:Lactobacillus gasseri OLL2716 as a

probiotic in clarithromycin-resistant

Helicobacter pylori infection. J Gastroenterol

Hepatol 2003, 18:986-991.

Cruchet S, Obregon MC, Salazar G, et al.:

Effect of the ingestion of a dietary product

containing Lactobacillus johnsonii La1 on

Helicobacter pylori colonization in children.

Nutrition 2003, 19:716-721.

Mukai T, Asasaka T, Sato E, et al.: Inhibition

of binding of Helicobacter pylori to the

glycolipid receptors by probiotic Lactobacillus

reuteri. FEMS Immunol Med Microbiol 2002,

:105-110.

McNaught CE, Woodcock NP, MacFie J, et al.:

A prospective randomised study of the

probiotic Lactobacillus plantarum 299V on

indices of gut barrier function in elective

surgical patients. Gut 2002, 51:827-831.

Sen S, Mullan MM, Parker TJ, et al.: Effect of

Lactobacillus plantarum 299v on colonic

fermentation and symptoms of irritable bowel

syndrome. Dig Dis Sci 2002, 47:2615-2620.

Gionchetti P, Amadini C, Rizzello F, et al.:

Probiotics for the treatment of postoperative

complications following intestinal surgery.

Best Pract Res Clin Gastroenterol 2003,

:821-831.

Rayes N, Seehofer D, Muller AR, et al.:

[Influence of probiotics and fibre on the

incidence of bacterial infections following

major abdominal surgery- results of a

prospective trial]. Z Gastroenterol 2002,

:869-876

Gary W. Elmer, PhD; Christina M. Surawicz,

MD; Lynne V. McFarland, PhD , A Neglected

Modality for the Treatment and Prevention of

Selected Intestinal and Vaginal Infections

.JAMA. 1996;275(11):870-876.

Akyol S, Mas MR, Comert B, et al.: The

effect of antibiotic and probiotic combination

therapy on secondary pancreatic infections and

oxidative stress parameters in experimental

acute necrotizing pancreatitis. Pancreas 2003,

:363-367.

Guandalini S, Pensabene L, Zikri MA, et

al.:Lactobacillus GG administered in oral

rehydration solution to children with acute

diarrhea: a multicenter European trial. J Pediatr

Gastroenterol Nutr 2000, 30:54-60.

Surawicz CM: Probiotics, antibiotic-associated

diarrhoea and Clostridium difficile diarrhoea in

humans. Best Pract Res Clin Gastroenterol

, 17:775- 783.

Kelleher SL, Casas I, Carbajal N, et al.:

Supplementation of infant formula with the

probiotic Lactobacillus reuteri and zinc: impact

on enteric infection and nutrition in infant

rhesus monkeys. J Pediatr Gastroenterol Nutr

, 35:162-168.

McFarland LV, Surawicz CM, Greenberg RN,

et al.: A randomized placebo-controlled trial of

Saccharomyces boulardii in combination with

standard antibiotics for Clostridium difficile

disease. JAMA 1994, 271:1913-1918.

Isolauri E: Probiotics for infectious diarrhoea.

Gut 2003, 52:436-437

50. Huang JS, Bousvaros A, Lee JW, et al.:

Efficacy of probiotic use in acute diarrhea

in children: a meta-analysis. Dig Dis Sci 2002,

:2625-2634.

Sambol SP, Merrigan MM, Tang JK, et al.:

Colonization for the prevention of

Clostridium difficile disease in hamsters. J

Infect Dis 2002, 186:1781-1789.

Cremonini F, Di Caro S, Nista EC, et al.: Metaanalysis: the effect of probiotic

administration on antibiotic-associated

diarrhoea. Aliment Pharmacol Ther 2002,

:1461-1467.

D'Souza AL, Rajkumar C, Cooke J, et al.:

Probiotics in prevention of antibiotic

associated diarrhoea: meta-analysis. BMJ 2002,

:1361.

Ahuja MC, Khamar B: Antibiotic associated

diarrhoea: a controlled study comparing plain

antibiotic with those containing protected

lactobacilli. J Indian Med Assoc 2002,

:334-335.

Sullivan A, Barkholt L, Nord CE:Lactobacillus

acidophilus, Bifidobacterium lactis and

Lactobacillus F19 prevent antibiotic-associated

ecological disturbances of Bacteroides fragilis

in the intestine. J Antimicrob Chemother 2003,

:308-311

Payne S, Gibson G, Wynne A, et al.:In vitro

studies on colonization resistance of the human

gut microbiota to Candida albicans and the

effects of tetracycline and Lactobacillus

plantarum LPK. Curr Issues Intest Microbiol

, 4:1-8.

Kim HJ, Camilleri M, McKinzie S, et al.: A

randomized controlled trial of a probiotic,

VSL#3, on gut transit and symptoms in

diarrhoea-predominant irritable bowel

syndrome. Aliment Pharmacol Ther 2003,

:895-904.

Costa-Ribeiro H, Ribeiro TC, Mattos AP, et

al.: Limitations of probiotic therapy in acute,

severe dehydrating diarrhea. J Pediatr

Gastroenterol Nutr 2003, 36:112-115.

Brigidi P, Vitali B, Swennen E, et al.: Effects

of probiotic administration upon the

composition and enzymatic activity of human

fecal microbiota in patients with irritable bowel

syndrome or functional diarrhea. Res Microbiol

, 152:735-741.

Femia AP, Luceri C, Dolara P, et al.:

Antitumorigenic activity of the prebiotic inulin

enriched with oligofructose in combination

with the probiotics Lactobacillus rhamnosus

and Bifidobacterium lactis on azoxymethaneinduced colon carcinogenesis in rats.

Carcinogenesis 2002, 23:1953-1960.

Sen S, Mullan MM, Parker TJ, et al.: Effects of

Lactobacillus plantarum 299v on symptoms

and colonic fermentation in irritable bowel

syndrome (IBS). Gut 2001, 48(suppl 1):A57.

O'Sullivan MA, O'Morain CA: Bacterial

supplementation in the irritable bowel

syndrome. A randomised double-blind

placebo-controlled crossover study. Dig Liver

Dis 2000, 32:294-301.

Nobaek S, Johansson ML, Molin G, et al.:

Alteration of intestinal microflora is associated

with reduction in abdominal bloating and pain

in patients with irritable bowel syndrome. Am J

Gastroenterol 2000, 95:1231-1238.

Niedzielin K, Kordecki H, Kosik R: New

possibility in the treatment of irritable bowel

syndrome: probiotics as a modification of the

microflora of the colon. Gastroenterology

, 114:A402.

Bauer TM, Fernandez J, Navasa M, et al.:

Failure of Lactobacillus spp. to prevent

bacterial translocation in a rat model of

experimental cirrhosis. J Hepatol 2002, 36:501-

Tamboli CP, Caucheteux C, Cortot A, et al.:

Probiotics in inflammatory bowel disease: a

critical review. Best Pract Res Clin

Gastroenterol 2003, 17:805-820.

Hart AL, Stagg AJ, Kamm MA: Use of

probiotics in the treatment of inflammatory

bowel disease. J Clin Gastroenterol 2003,

:111-119.

Gionchetti P, Amadini C, Rizzello F, et al.:

Probiotics-role in inflammatory bowel disease.

Dig Liver Dis 2002, 34(suppl 2):S58-S62.

Bamba T, Kanauchi O, Andoh A, et al.: A new

prebiotic from germinated barley for

nutraceutical treatment of ulcerative colitis. J

Gastroenterol Hepatol 2002, 17:818-824.

Kanauchi O, Serizawa I, Araki Y, et al.:

Germinated barley foodstuff, a prebiotic

product, ameliorates inflammation of colitis

through modulation of the enteric environment.

J Gastroenterol 2003, 38:134-141.

Ishikawa H, Akedo I, Umesaki Y, et al.:

Randomized controlled trial of the effect of

bifidobacteria-fermented milk on ulcerative

colitis. J Am Coll Nutr 2003, 22:56-63.

Marteau PR, de Vrese M, Cellier CJ,

Schrezenmeir J. Protection from

gastrointestinal diseases with the use of

probiotics. Am J Clin Nutr 2001;73:430S–6S

Gan BS, Kim J, Reid G, et al.:Lactobacillus

fermentum RC-14 inhibits Staphylococcus

aureus infection of surgical implants in rats. J

Infect Dis 2002, 185:1369-1372.

Kecskes G, Belagyi T, Olah A: [Early jejunal

nutrition with combined pre- and probiotics in

acute pancreatitis-prospective, randomized,

double-blind investigations]. Magy Seb 2003,

:3-8.

Mangiante G, Colucci G, Canepari P, et

al.:Lactobacillus plantarum reduces infection

of pancreatic necrosis in experimental acute

pancreatitis. Dig Surg 2001, 18:47-50.

Delia P, Sansotta G, Donato V, et al.:

Prevention of radiation-induced diarrhea with

the use of VSL#3, a new high-potency

probiotic preparation. Am J Gastroenterol

, 97:2150-2152.

Li Z, Yang S, Lin H, et al.: Probiotics and

antibodies to TNF inhibit inflammatory activity

and improve nonalcoholic fatty liver disease.

Hepatology 2003, 37:343-350.

Solga SF: Probiotics can treat hepatic

encephalopathy. Med Hypotheses 2003,

:307-313.

Borody TJ, Warren EF, Leis S, et al.:

Treatment of ulcerative colitis using fecal

bacteriotherapy. J Clin Gastroenterol 2003,

:42-47.

Seksik P, Rigottier-Gois L, Gramet G, et al.:

Alterations of the dominant faecal bacterial

groups in patients with Crohn's disease of the

colon. Gut 2003, 52:237-242.

Guandalini S: Use of Lactobacillus-GG in

paediatric Crohn's disease. Dig Liver Dis 2002,

(suppl 2):S63-S65.

Gionchetti P, Rizzello F, Venturi A, et al.:

Antibiotic combination therapy in patients with

chronic, treatment-resistant pouchitis. Aliment

Pharmacol Ther 1999, 13:713-718.

Gionchetti P, Rizzello F, Helwig U, et al.:

Prophylaxis of pouchitis onset with probiotic

therapy: a double-blind, placebo-controlled

trial. Gastroenterology 2003, 124:1202-1209.

Cremonini F, Di Caro S, Covino M, et al.:

Effect of different probiotic preparations on

anti-Helicobacter pylori therapy-related side

effects: a parallel group, triple blind, placebocontrolled study. Am J Gastroenterol 2002,

:2744-2749.

Rafter J: Probiotics and colon cancer. Best

Pract Res Clin Gastroenterol 2003, 17:849-859.

Rafter J: Lactic acid bacteria and cancer:

mechanistic perspective. Br J Nutr 2002,

(suppl 1):S89-S94.

Brady LJ, Gallaher DD, Busta FF (February

. "The role of probiotic cultures in the

prevention of colon cancer". J. Nutr. 130 (2S

Suppl): 410S–414S

Obermeier F, Dunger N, Strauch UG, et al.:

Contrasting activity of cytosin-guanosin

dinucleotide oligonucleotides in mice with

experimental colitis. Clin Exp Immunol 2003,

:217-224.

Kalliomaki M, Salminen S, Poussa T, et al.:

Probiotics and prevention of atopic disease: 4-

year follow-up of a randomised placebocontrolled trial. Lancet 2003, 361:1869-1871.

Kirjavainen PV, Salminen SJ, Isolauri E:

Probiotic bacteria in the management of atopic

disease: underscoring the importance of

viability. J Pediatr Gastroenterol Nutr 2003,

:223-227.

Saavedra J, Probiotics and infectious

diarrhea.Am J Gastroenterol

;95(Suppl):S8-S18

McCarthy M, Breaking up the bacterial happy

home.Lancet 2001;23:357(9373):2032-2033

Kuisma J, Mentula S, Jarvinen H, et al.: Effect

of Lactobacillus rhamnosus GG on ileal pouch

inflammation and microbial flora. Aliment

Pharmacol Ther 2003, 17:509-515.

Borriello SP, Hammes WP, Holzapfel W, et

al.: Safety of probiotics that contain lactobacilli

or bifidobacteria. Clin Infect Dis 2003, 36:775-

Isolauri E, Kirjavainen PV, Salminen S:

Probiotics: a role in the treatment of intestinal

infection and inflammation? Gut 2002,

(suppl 3):III54-III59.

Riquelme AJ, Calvo MA, Guzman AM, et

al.:Saccharomyces cerevisiae fungemia after

Saccharomyces boulardii treatment in

immunocompromised patients. J Clin

Gastroenterol 2003, 36:41-43.

Collins MD, et al. Reduces the risk of

antibiotic, allergic and infectious diarrhoea.

Am J Clin Nutr 1999; 69(suppl):1052s-7s. 153-

Downloads

Published

06/30/2010

Issue

Section

Review Article