Ethosomes-A Priority in Transdermal Drug Delivery
Keywords:
Ethosomes, Vesicle, Transdermal drug deliveryAbstract
Transdermal drug delivery system was first introduced more than 20 years ago. The technology generated tremendous excitement and interest amongst major pharmaceutical companies in the 1980s and 90s. By the mid to late 1990s, the trend of transdermal drug delivery system merged into larger organizations. Transdermal drug delivery system is a type of convenient drug delivery system where drug goes to the systemic circulation through the protective barrier i.e. Skin. Over the year it has showed promising result in comparison to oral drug delivery system as it eliminates gastrointestinal interferences and first pass metabolism of the drug but the main drawback of TDDS is it encounters the barrier properties of the Stratum Corneum i.e. only the lipophilic drugs having molecular weight < 500 Da can pass through it. Ethosomes have been found to be much more efficient in delivering drug to the skin; Ethosomes are the non invasive drug delivery carriers that enable drugs to reach the deep skin layers finally delivering to the systemic circulation. For optimal skin delivery, drug should be efficiently entrapped within ethosomal vesicles. Ethosomal drug delivery system is a new state of the art technique and easier to prepare in addition to safety and efficacy. Ethosomes have become a area of research interest, because of its enhanced skin permeation, improved drug delivery, increased drug entrapment efficiency etc
References
Croock D, The metabolic consequences of
treating postmenopausal women with normal
hormone replacement therapy, Br. J. Obstet.
Gynaecol., 1997;104:4-13.
Touitou E, Drug delivery across the skin, Expert
Opin. Biol. Ther., 2002; 2:723-733.
Merdan VM, Alhaique F, and Touitou E,
Vesicular carriers for topical delivery. Acta
Techno. Legis Medicament., 1998; 12:1-6.
Touitou, E. Composition of applying active
substance to or through the skin, US patent,
; 5:716,638.
Berner, B.Liu, P. Alcohol, In Percutaneous
Enhancer, Smith, E.W.; Maibach, H.I., Ed.;
CRC Press, Boca Raton, FI., 1995: 45-60.
Riaz, M.; Weiner, N.; Martin, F. Liberman,
H.A.; Reiger, M.M.; Banker, G.S., Ed.; Marcel
Dekker, New-York, Basel, In Pharmaceutical
Dosage forms, Disperse Systems., 1998; 2:567-
Touitou, E. Composition of applying active
substance to or through the skin, US patent,
; 5:716,638
Barry, B.W. Novel mechanisms and devices to
enable successful transdermal drug delivery
Eur. J. Pharm. Sci. 2001; 14:101-114.
Verma, D.D. and Fahr, a Synergistic penetration
effect of ethanol and phospholipids on the
topical delivery of Cyclosporin A. J. Control
Release. 2004; 97:55-66.
Touitou, E. Composition of applying active
substance to or through the skin, US patent,
; 5:540,934
Touitou E, Dayan N, Bergelson L, Godin B,
Eliaz M, Ethosomes-novel vesicular carriers for
enhanced delivery: characterization and skin
penetration properties. J. Control. Release,
; 65: 403-418.
Guo J, Ping Q, Sun G, and Jiao C, Lecithin
vesicular carriers for transdermal delivery of
cyclosporine A. Int. J. Pharm.,
;194(2):201-207.
Fry DW, White JC, and Goldman ID, Rapid
secretion of low molecular weight solutes from
liposomes without dilution. Anal. Biochem,
; 90:809-815.
Dayan, N and Touitou, Carrier for skin delivery
of trihexyphenidyl HCl: Ethosomes vs.
liposomes.E. Biomaterials. 2000; 21:1879-1885.
El Maghraby GMM, Williams AC, and Barry
BW, Oestradiol skin delivery from
ultradeformable liposomes refinement of
surfactant concentration. Int. J. Pharm., 2000;
(1):63-74.
Dayan N, and Touitou E, Carrier for skin
delivery of trihexyphenidyl HCl: Ethosomes vs
liposomes. Biomaterials, 2002; 21:1879-1885
Cevc G, Schatzlein A, and Blume G,
Transdermal drug carriers: Basic properties,
optimization and transfer efficiency in case of
epicutaneously applied peptides, J. Control.
Release, 1995; 36:3-16.
Vanden Berge BAI, Swartzendruber VAB, and
Geest J, Development of an optimal protocol for
the ultrastructural examination of skin by
transmission electron microscopy. J. Microsc.,
; 187(2):125-133.
New RRC, Preparation of liposomes and size
determination, In:Liposomes A Practical
Approach, New RRC (Ed.), Oxford University
Press, Oxford, 1990:36-39.
Toll R, Jacobi U, Richter H, Lademann J,
Schaefer H, and Blume U, Penetration profile of
microspheres in follicular targeting of terminal
hair follicles, J. Invest. Dermatol, 2004;
:168-176.
Jain S, Umamaheshwari RB, Tripathi P, Jain N
K. Ultradeformable liposomes: A recent tool
for effective transdermal drug delivery. Ind J
Pharm Sci. 2003; 65:223-231.
New, R.R.C., In Liposomes: A practical
approach, Oxford University Press, Oxford
El. Maghraby, G.M.M.; Williams, A.C; Barry,
B.W Oestradiol skin delivery from deformable
liposomes: refinement of surfactant
concentration Int. J. Pharm. 2000; 196:63-74.
Simonetti, O, Hoogstraate, AJ, Bilaik, W,
Kempenaar, JA, Schrijvers, AHG, Boddé, HE &
Ponec, M. Visualization of diffusion pathways
across the stratum corneum of native and in
vitro reconstructed epidermis by confocal laser
scanning microscopy. Arch Dermatol Res,
; 287, 465–473,
Honeywell-Nguyen, P.L.; Graaff, D.; Anko, M.;
Groenink, H.W.; Bouwstra, J.A. vesicle
approaches in transdermal delivery Biochim.
Biophys. Acta. 2002; 1573:130-138.
Touitou, E.; Dayan, N.; Bergelson, L.; Godin,
B.; Eliaz, M. Decresing systemic toxicity via
transdemal delivery of anti cancer drugs J.
Control. Release. 2008; 65: 403-418.
Jain S, Jain N, Bhadra D, Tiwary AK, Jain NK.
Vesicular Approach for Drug Delivery into or
Across the Skin: Current Status and Future
Prospects Current Drug Delivery 2005;
(3):222-233.
Dayan N, Touitou. Carrier for skin delivery of
trihexyphenidyl HCl: Ethosomes vs. liposomes
E. Biomaterials.2000; 21:1879-1885.
Jain S, Jain P, Jain NK. Vesicular Approach for
Drug Delivery into or Across the Skin: Current
Status and Future Prospects Current Drug
Delivery Ind. Pharm. 2003; 29(90):1013-1026.
Lopez-Pinto JM, Gonzalez-Rodriguez ML,
Rabasco AM. Effect of cholesterol and ethanol
on dermal delivery from DPPC liposomes. Int J
Pharm. 2005; 298:1-12.
Kelly HW, Murphy S.Beta-Adrenergic agonists
for acute, severe asthma. Ann pharmacother
; 26:81-91
Lauer AC, Ramachandran C, Lieb L.M,
Niemiec S, Weiner ND. Targeted delivery to
the pilosebaceous unit via liposomes. Adv. Drug
Delivery 1996; 18: 311-324.
Johnsen SG, Bennett EP, Jensen, VG Lance,
Therapeutic effectiveness of oral testosterone.
; 2:1473-1475.
Jain S, Vesicular approaches for transdermal
delivery of bioactive agent. Ph.D thesis, Dr.
H.S. Gour University, Sagar, India, 2005.
Tuting TH, Storkus WJ, Falo J. DNA
Immunization Targeting the Skin: Molecular
Control of Adaptive Immunity J. Invest.
Dermatol. 1998; 111:183-188.
Fang J, Hong C, Chiu W, Wang Y. Effect of
liposomes and niosomes on skin permeation of
enoxacin. Int. J. Pharm. 2001; 219: 61-72.
Kim S, Chien YW. Toxicity of cationic lipids
and cationic polymers in gene delivery J.
Control. Release. 1996; 40: 67-76.
Jain S, Uma Maheshwari RB, Bhadra D, Jain
NK, Ethosomes: A novel vesicular carriers for
enhanced transdermal delivery of an anti HIV
agent. Ind J Pharm Sci 2004; 66:72-81..
Spruance, S.L. Semin The natural history of
recurrent oral facial herpes simplex virus infec
tion. Dermatol. 1992; 11:200-206.
Fiddan AP, Yeo JM, Strubbings R, Dean D.
Vesicular Approach for Drug Delivery into or
Across the Skin Br. Med. J. 1983; 286, 701,
Horwitz E, Pisanty S, Czerninsky R, Helser M,
Eliav E, Touitou E. Oral Surg Oral Pathol Oral
Radiol Endod, 1999; 88:700-05.
Chetty DJ, Chien YW. Transdermal Delivery of
CaCO3-Nanoparticles Containing Insulin Crit
Rev Ther Drug Carrier Syst.1998; 15: 629-670.
Verma DD, Fahr A. Synergistic penetration
effect of ethanol and phospholipids on the
topical delivery of Cyclosporin A. J. Control
Release.2004; 97:55-66.
Paolino D, Lucania G, Mardente D, Alhaique F,
Fresta M. Innovative Drug Delivery Systems for
the Administration of Natural Compounds J.
Control. Release. 2005; 106: 99-110.
Fu Y, Hsieh J, Guo J, Kunicki J, Lee MY,
Darzynkiewicz Z, Wu J.M, Licochalcone A.
Anti-inflammatory efficacy of Licochalcone A:
correlation of clinical potency and in vitro
effects Biochem. Biophys. Res. Commun. 2004;
: 263-270.
