An approach for solubility enhancement: solid dispersion
Keywords:
Aceclofenac, hydrophilic carrier, Aerosil 200, solvent evaporation methodAbstract
The solubility behavior of drug is one of most challenging aspect in formulation development. Thus a greater understanding of dissolution & absorption behavior of drug with low aqueous solubility is required to successfully formulate them into more soluble and hence bioavailable drug product. Therefore different approaches are being explored to enhance the solubility of poorly water soluble drugs, one of such approach is using solid dispersion by solvent evaporation method. In this study, we are trying to increase the solubility of aceclofenac, poorly water soluble drug with low bioavailability. Objective of this work is to improve the solubility and dissolution rate of poorly water soluble Aceclofenac by solid dispersion method followed by solvent evaporation method. And to compare effectiveness of hydrophilic polymer PVP-k30, HPMC E-5, using porous carrier Aerosil 200. , resultant complexes were evaluated for drug content, infrared spectroscopy, and XRD and dissolution study. The present study successfully utilized the solvent evaporation method for preparation of stable, amorphous solid dispersions of Aceclofenac by encapsulation with hydrophilic carrier with adsorbents agent (Batch 4, 1:1:2) drug: PVPK30: aerosil, showed maximum release in phosphate buffer pH 6.8 The present study demonstrates high potential of solvent evaporation method for obtaining large surface area and amorphicity of drug using hydrophilic carrier
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