Investigating the phase-solubility and compatibility study of anticancer drug complexed with β-cyclodextrin and HP–β-cyclodextrin
Keywords:
gefitinib, cyclodextrins, complexation, DSC, FTIRAbstract
Poor aqueous solubility and dissolution rates are critical problems that hinders the formulation, development and delivery of most of BCS class II and class IV drugs. Gefitinib is a cytotoxic chemotherapeutic drug used in treatment of cancer. The objective of the present study was to investigate the drug-cyclodextrin compatibility study by FTIR and DSC study. The phase solubility study revealed formation of 1:1 stoichiometry binary inclusion complex. The complex was prepared by kneading method. FT-IR spectra provided the data indicating that the HP-β-CD was more effective than β-CD. Differential scanning calorimetry thermograms indicated stronger amorphization and entrapment of gefitinib with HP-β-CD.
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